Research Projects

View our directory of the latest ageing research projects here, complete with the contact details of related researchers and research centres. To view CARDI projects click the button to the right.

Displaying 11 - 20 of 74


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Decision-making regarding medication use in patients with dementia at the end of life

CARDI Involvement

Project Lead

Dr Carole Parsons, Lecturer in Pharmacy Practice, Queens University Belfast

Researchers: 

  • Professor Carmel Hughes, Chair in Primary Care Pharmacy, Queen's University Belfast
  • Professor Peter Passmore, Department of Geriatric Medicine, Queen's University Belfast
  • Dr Denis O'Mahony, University College Cork
  • Dr Stephen Byrne, University College Cork
  • Alzheimer's Society (NI) and the Alzheimer's Society of Ireland (ROI)
Despite the increase in the prevalence and incidence of dementia research into palliative care for patients with advanced dementia is limited. This novel study will seek to evaluate, in Ireland (North and South), the extent to which patient-related factors influence clinical decision-making in respect to medication use in patients with end-stage dementia. 
CARDI grant programme

Diet, retinal microvascular health and cognitive decline and dementia risk

CARDI Involvement

Project Lead

Dr Charlotte Neville
  • Centre for Public Health, QUB

Mentor: Professor Jayne Woodside, QUB

For the CARDI Leadership Programme Dr Charlotte Neville will explore the impact of stress on the neurocognitive and cardiovascular health of older adults in the North and South of Ireland, using data from NICOLA and TILDA. The experience of severe or persistent psychological stress can alter immune mediators, trigger inflammatory processes and increase oxidative stress, damaging brain and cardiovascular health.

CARDI grant programme

Does pain mediate or moderate the protective effects of physical activity on depressive symptoms in older people?

CARDI Involvement

Project Lead

Dr Frank Doyle, Psychology, Royal College of Surgeons in Ireland

Researchers: 

  • Division of Population Health Sciences (Psychology)
    RCSI - Royal College of Surgeons in Ireland
  • Professor Ronan Conroy, Biostatistics, Epidemiology, RCSI
  • Dr Anne Hickey, Psychology, RCSI
  • Dr Caroline Kelleher, Psychology, RCSI
Moderate to high levels of physical activity can reduce the odds of having depression by half or more. Pain has been shown to be associated with a greater risk of depression among older people and also a potential reason for not engaging in physical activity.

Dr Doyle will investigate the extent to which pain interacts with depression and physical activity in Ireland, north and south, which has potentially crucial clinical and policy implications for older people.

CARDI grant programme

Encouraging behaviour change in mild cognitive impairment patients: development of educational materials

CARDI Involvement

Project Lead

Dr Jayne Woodside, Senior Lecturer of Nutrition, Centre for Public Health, Queen’s University Belfast

Researchers: 

  • Dr Bernadette McGuinness, Senior Clinical Research Fellow, Geriatric Medicine and Dr Michelle McKinley, Lecturer in Nutrition and Professor Peter Passmore, Professor Geriatric Medicine, Queens University Belfast
  • Professor Brian Lawlor, Professor of Psychiatry, and Dr Robert Coen, Lecturer in Clinical Psychology, Trinity College Dublin
  • Mr Matthew Gibb, Senior Social Worker, Dementia Services Information and Development Centre, St James’s Hospital Dublin.
 
Cognitive decline has a profound impact on the health and quality of life of older people and care-givers.  Randomised controlled trials could identify at which stage interventions are most effective but educational materials on behaviour change are needed first.
 

Objectives

To use focus groups of mild cognitive impairment patients and their care-givers and to hold structured interviews with professionals to design and test educational materials that can encourage change in diet and physical activity.
CARDI grant programme

Examination using functional MRI and diffusion tensor imaging...

Researchers: 

  • Full title: Examination using functional MRI and diffusion tensor imaging of alterations in working memory network in Mild Cognitively Impaired subjects
  • Investigation of changes in brain activation due to normal ageing and due to Mild Cognitive Impairment in emotional modulation of long term memory.

 

Examining inequalities in health and health behaviours

CARDI Involvement

Project Lead

Dr Eibhlin Hudson, Trinity College Dublin

Researchers: 

  • Dr Irene Mosca, Economics, Trnity College Dublin
  • Professor David Madden, Economics, University College Dublin
Health behaviours are significant barriers to healthy ageing but little is known about how they differ by socio-economic status.

This study examines inequalities in Ireland, north and south, in health behaviours and outputs, such as smoking, alcohol consumption, body mass index and physical activity. It also looks at changes over time.

Dr Hudson is developing a technique known as a concentration index – a single measure of inequality which can be decomposed to analyse factors underlying inequality.

CARDI grant programme

Frailty and disability in Ireland

CARDI Involvement

Project Lead

Dr Matthew O’Connell, Trinity College Dublin

Researchers: 

  • Dr Bellinda King-Kallimanis, Statistics, Trinity College Dublin
  • Professor Rose Anne Kenny, Geriatric Medicine, Trinity College Dublin
Disability in older adults is associated with reduced physical activity, loss of independence, reduced quality of life and increased health care costs. It is more prevalent in Northern Ireland than in the Republic of Ireland.

Key Findings:

CARDI grant programme

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